Most experts now consider MOG-IgG-associated encephalomyelitis (MOG-EM) a disease entity in its own right, immunopathogenetically distinct from both classic multiple sclerosis (MS) and aquaporin-4 (AQP4)-IgG-positive neuromyelitis optica spectrum disorders (NMOSD). the past few years, new-generation cell-based assays have demonstrated a robust association of autoantibodies to full-length human myelin oligodendrocyte glycoprotein (MOG-IgG) with (mostly recurrent) optic neuritis, myelitis and brainstem encephalitis, as well as with acute disseminated encephalomyelitis (ADEM)-like presentations. 20 Molecular Neuroimmunology Group, Department of Neurology, University Hospital Heidelberg, Im Neuenheimer Feld 350, 69120, Heidelberg, Germany.19 Department of Neurology, Mayo Clinic, Rochester, MN, USA.18 Department of Neurology, Hannover Medical School, Hanover, Germany.17 Service of Neurology, Hospital Clinic, and Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Universitat de Barcelona, Barcelona, Spain.
16 Department of Neurology, Charité - Universitätsmedizin Berlin, Berlin, Germany.15 Nuffield Department of Clinical Neurosciences, John Radcliffe Hospital, Oxford, UK.14 Department of Neurology, Johns Hopkins Hospital, Cleveland, USA.13 Institute of Clinical Neuroimmunology, Ludwig Maximilian University, Munich, Germany.12 Department of Neurology, Ruhr University Bochum, Bochum, Germany.11 Department of Neurology, Research Institute and Hospital of National Cancer Center, Goyang, South Korea.10 The Walton Centre, Walton Centre NHS Foundation Trust, Liverpool, UK.9 Department of Multiple Sclerosis Therapeutics, Tohoku University Graduate School of Medicine, Sendai, Japan.8 IRCCS, National Neurological Institute C.7 Department of Neurology, Hôpital de Hautepierre, Strasbourg Cedex, France.6 Children's Hospital at Westmead, University of Sydney, Sydney, Australia.5 Department of Neurology, University of Southern Denmark, Odense, Denmark.
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